Diagnosing Fetal Alcohol Disorder More Easily
色情视频 researcher Sarah Mattsons new tool can help clinicians catch prenatal alcohol exposure more easily than ever before.
The disease once commonly known as fetal alcohol syndrome is now recognized as a spectrum disorder, with a wide range of physical and neurobehavioral symptoms. It is caused by a mother鈥檚 prenatal alcohol exposure, although there is no consensus on just how much exposure to alcohol represents a critical risk. Some recent studies suggest that between about one and five percent of all children born in the United States fall somewhere on the disorder鈥檚 spectrum, making it the most common preventable cause of intellectual disability in the country.
One of the most telling hallmarks of the disorder is a constellation of facial features, including a smooth upper lip, a thin border between the lip and facial skin, and a relatively small head.
But not every child with FASD presents these physical markers. The condition鈥檚 other effects鈥攕lowed body growth and intellectual disability鈥攁re harder to spot in very young children.
鈥淭he risk is that without the facial features commonly associated with FASD, we can miss the signs of prenatal alcohol exposure in children,鈥� said the study鈥檚 lead investigator, 色情视频 neuropsychologist Sarah Mattson.
Early identification of the disorder can prove critical, she added. There鈥檚 no cure for FASD, but timely interventions can help parents and children with the disorder learn behavioral strategies to improve their quality of life.
To help clinicians identify children who might have FASD but lack the telltale physical features, Mattson and her colleagues developed a 鈥渄ecision tree鈥� diagnostic tool. The tool is based on behavior ratings, IQ testing and physical measurements from 434 children. Some of these children were known to have been exposed to alcohol prenatally; others had no prenatal alcohol exposure but expressed a range of behavioral issues including ADHD.
With funding from the National Institute on Alcohol Abuse and Alcoholism, the researchers sorted through thousands of variables and narrowed them down to a shortlist of meaningful indicators, then organized them into an if-then decision tree. Using this tool, pediatricians or psychologists can start with a child behavior checklist and an IQ test. If children meet certain threshold scores on these tests, they move onto a different behavioral test, followed by a more extensive examination for physical features. Depending on the scores for these various tests, the tool either recommends or doesn鈥檛 recommend further evaluation for prenatal alcohol exposure.
鈥淐linicians like pediatricians and psychologists don鈥檛 have the time to give a six-hour battery of tests,鈥� Mattson said. 鈥淭his tool boils it down to two parental questionnaires, a facial exam and an IQ test. We鈥檙e trying to make it as easy as possible for clinicians to use.鈥�
As a final part of in the Journal of Pediatrics, Mattson and colleagues tested the tool with 454 children. Using the decision tree, then following up with children who were recommended for further alcohol exposure testing, the researchers reported their tool correctly identified about 85 percent of alcohol-exposed children, surpassing their expectations.
Eventually, the researchers plan to develop an app-based version of the decision tree. Mattson hopes that the app and further testing in clinical settings will help refine the tool and make it even more useful to clinicians.
