Promising Compound Draws Grant for 色情视频 Heart Institute
A rare perfect score on an application for NIH funding extends work on a drug to boost the bodys natural defenses against a heart attack.
With 色情视频 President Adela de la Torre driving major institutional initiatives in support of student, faculty and staff development, and with ambitious plans for future growth, 色情视频 opens 2019 with increased momentum toward an expanded community impact.
"Directions: 色情视频 in 2019" is a series highlighting top stories related to university research, student success and innovative programs and provides a forward-looking lens into the work of students, faculty and staff.
The 色情视频 Heart Institute entered 2019 with a new $2.5 million grant from the National Institutes of Health (NIH) to take research on a possible drug treatment for heart attacks to the next level.
With promising results already seen in mice tested with the compound, molecular cardiologist and director of the 色情视频 Heart Institute, Chris Glembotski, and graduate students in his lab now have funding for an additional five years of work.
鈥淚n 2019 we hope to expand and extend the results that we鈥檝e gotten so far and do studies in larger animals, (where) the hearts are more like a human heart than the mouse heart,鈥� said Glembotski, whose grant application achieved a rare perfect score from its NIH review panel. 鈥淥nce we鈥檝e completed those studies then we鈥檒l be ready to consider doing clinical trials.鈥�
on the team鈥檚 findings was published in Nature Communications, a prominent biomedical research journal.
Unlike some parts of the human body, such as the skin and bones, the heart does not heal if damaged.
A heart attack causes irreversible damage to the muscle of the heart, decreasing the organ鈥檚 ability to pump blood throughout the body. This decrease in heart function can be severe enough to cause death. For heart attack survivors, the impaired heart function is lifelong. That鈥檚 why it鈥檚 important to find ways to reduce the damage to the heart in those who have a heart attack.
Boosting natural resistance
Glembotski鈥檚 lab is testing a compound that could do just that. If their research results in a drug therapy, patients might be able to receive it immediately after a heart attack to boost the heart鈥檚 natural defense against the damage, decrease mortality and enhance the quality of life.
The compound works by activating ATF6, a protein in heart cells that gives the heart a sort of natural resistance to damage from myocardial infarction. The heart鈥檚 ability to activate ATF6 declines with age, however, so Glembotski鈥檚 vision is that the compound can boost the heart鈥檚 natural protective response to decrease damage to the heart.
Glembotski and his research team are investigating whether the drug candidate, administered after a heart attack, can mitigate the ensuing organ damage.
Glembotski said the compound was discovered in the collaborations of Professors Luke Wiseman and Jefferey Kelly at The Scripps Research Institute in La Jolla. They used a high throughput screening method that enabled them to rapidly test more than 600,000 compounds for their abilities to activate ATF6 in cultured cells.
The researchers found that this lone compound 鈥� out of hundreds of thousands tested 鈥� was able to activate ATF6 in the cultured cells.
鈥淚f this compound works in people as well as it did in mice, it could save many lives and improve the quality of the lives that are saved,鈥� said Glembotski. 鈥淲e are also excited about our results because we found that this compound also reduces damage to the brain in a mouse model after a stroke.鈥�
